this has happened a few times now. i've been playing diablo 3 (MCE works pretty darn well btw) in windowed mode on my triple monitor set up. because of this i have vertical bars on either side of the game where if you click, the desktop becomes the process in the foreground. at random the curser will immedeitly zip over to the top left corner (or bottom left once) and so long as i hold the hydra in my hands and its not settled on the base station, the curser will remain there. so i die. the only way i've found to fix this is to restart the motioncreater 2.0 program and reset the aim.
revised statement: sometimes it'll stick to the corner, other times it just really wants to go left and i can still move aim up an down. when i can move it up and down i can just re-center the curser by clicking the rt joystick and i can continue playing (although im probably dead anyway, grrr).
either way my unit has a facination with going left at random, very very fast. i havent tested to see if this happens in other games yet, but if anyone else playing diablo 3 see's this, does it happen to you too?